CN1105722C含氮杂环自由基的青蒿素衍生物及其制备方法---该衍生物具有抗原虫、抗癌、调节免疫、抗炎、杀虫等作用|CN1105722C Artemisinin derivatives containing nitrogen heterocyclic free radicals and preparation methods thereof---The derivative exhibits anti-parasitic, anti-cancer, immunomodulatory, anti-in
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CN1105722C含氮杂环自由基的青蒿素衍生物及其制备方法---该衍生物具有抗原虫、抗癌、调节免疫、抗炎、杀虫等作用
CN1105722C Artemisinin derivatives containing nitrogen heterocyclic free radicals and preparation methods thereof---The derivative exhibits anti-parasitic, anti-cancer, immunomodulatory, anti-inflammatory, and insecticidal effects.
含氮杂环基的青蒿素衍生物及其制备方法
一类含氮杂环基的青蒿素衍生物及其制备方法：它们可由乙酰二氢青蒿素(或三氟乙酰二氢青蒿素，次甲基青蒿素，二氢青蒿素，β-溴代蒿乙醚，2，3-环氧蒿丙醚)与氮杂环化合物(或含有羧基的氮杂环化合物，含有羟基的氮杂环化合物)反应生成。经初步药理筛选，发现它们具有抗原虫，抗癌，免疫调节，抗炎，杀虫等作用。
含氮杂环基的青蒿素衍生物及其制备方法
本发明涉及稠环系含有氮原子作为杂环原子的杂环化合物，具体说是含有氮杂环基的青蒿素衍生物及其制备方法。
青蒿素是中药青蒿(植物黄花蒿Artemisia annua L)的抗疟有效成份，有治疗抗药性疟疾和速效、低毒的特点。国内外科学家制备了大量青蒿素的衍生物，其中含氮杂环基的青蒿素衍生物有如下报导：(一)式中，...
Arteannuin derivant containing azacyclic radical and preparation process thereof
The present invention relates to arteannuin derivatives containing nitrogen heterocyclic groups and a preparing method thereof. The derivatives can be generated by the reaction of acetyl dihydroarteannuin (or trifluoroacetyl dihydroarteannuin, methenyl arteannuin, dihydroarteannuin, beta-bromoarteether and 2, 3-epoxyartemisic propyl ether) and a nitrogen heterocyclic compound (or a nitrogen heterocyclic compound containing carboxyl or a nitrogen heterocyclic compound containing hydroxyl). Primary pharmacological screening tests find that the derivatives have functions of resisting protozoons and cancer, regulating immunity, resisting inflammation, killing insects, etc.
Artemisinin derivative of nitrogen heterocycle and preparation method thereof
The present invention relates to condensed ring system and contain the heterogeneous ring compound of nitrogen-atoms as heterocyclic atom, is artemisinin derivative that contains Azacyclyl and preparation method thereof specifically.
Artemisinin is the antimalarial effective ingredient of Chinese medicine sweet wormwood (plant Artemisia annua Artemisia annua L), and treatment resistant malaria and characteristics quick-acting, low toxicity are arranged.Scientist has prepared the derivative of a large amount of Artemisinins both at home and abroad, and wherein the artemisinin derivative of nitrogen heterocycle has following report: (1) in the formula,...
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