CN1264508C治疗妇科病的青蒿素制剂---青蒿素制剂对妇科具有良好的抑制或杀灭作用。阴道霉菌病、滴虫和其他病原体|CN1264508C Artemisinin preparation for treating gynecological diseases---Artemisinin preparations exhibit good inhibitory or killing effects on gynecological conditions such as vaginal candidiasi
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CN1264508C治疗妇科病的青蒿素制剂---青蒿素制剂对妇科具有良好的抑制或杀灭作用。阴道霉菌病、滴虫和其他病原体
CN1264508C Artemisinin preparation for treating gynecological diseases---Artemisinin preparations exhibit good inhibitory or killing effects on gynecological conditions such as vaginal candidiasis, trichomoniasis, and other pathogens.
治疗妇科疾病的青蒿素制剂
本发明提供一种治疗妇科疾病的青蒿素制剂，它由药用辅料以及药物有效成分制成医药上可接受的制剂，其特征在于药物有效成分为青蒿素或其衍生物，且每个最小制剂单元含有青蒿素或其衍生物0.02g-1.0g。对妇科霉菌性阴道炎、滴虫等病原菌有良好的抑制或杀灭作用。加之使用了柠檬酸等有机酸来调整药物的pH值，使之在病灶所处的酸性环境中也能充分发挥其药效，由于还可配入适宜的芳香剂，使药物更具芳香化浊的效果，同时药物散发出来的宜人清香，适应了人体生理的人性化设计。另本发明还具有内在质量优秀、外在质量宜人等特点，从而可大大提高患者使用的依从性，进而为提高疗效乃至根治疾病打下基础。
治疗妇科疾病的青蒿素制剂
技术领域
本发明涉及一种治疗妇科疾病的青蒿素药物制剂，属医药的技术领域。
背景技术
妇科疾病是严重危害妇女身心健康的疾病，在妇科疾病中最为常见的是滴虫性阴道炎、霉菌性阴道炎等，这主要与女性外生殖道的特殊环境有关。青蒿为一种常用中药，其入药最早见于马王堆三号汉墓出土的《五十二病方》。青蒿(Artemisia annua L)，性寒味苦，常用来清热、解暑。据李时珍的《本草纲目》记载：青蒿主治皮肤病、鼻出血、痔疮便血、疟疾、虚热等。自二十世纪七十年代，中国科学家首次从青蒿中分离提取出抗疟新药—青蒿素以来，青蒿素引起了医药界的广泛关注。目前已上市的青蒿素及其衍生物有：青蒿素、蒿甲醚、青蒿琥酯、双氢青蒿素、蒿乙醚、蒿醚林酸等，并且国内外都还在不断地研究青蒿素的新的衍生物。青蒿素及其衍生物在医药领域中的应用及研究已有过报道，但在妇科疾病如滴虫性阴道炎、霉菌性阴道炎等的研究与应用则未见报道。
发明内容
本发明的目的旨在提供一种质量稳定、安全性好、疗效优越的治疗妇科疾病的青蒿素药物制剂。
本发明根据妇科疾病的特点，结合本发明对青蒿素类药学药效毒理的研究，将药物开发为直接作用在病灶的制剂。
本发明通过下列技术方案实现：它由药用辅料以及药物有效成分制成医药上可接受的制剂，其特征在于药物有效成分为青蒿素或其衍生物，且每个最小制剂单元含有青蒿素或其衍生物0.02g-1.0g。
所述药用辅料是羟丙环糊精、聚异丁烯酸甘油酯、乙醇、丙二醇、乙基纤维素、羟丙甲纤维素、PEG-10000、羟甲基纤维素、可溶性淀粉、明胶、甘油、月见草油、花生油、维生素E、聚乙二醇、羟乙烯聚合物、三乙醇胺中的一种或几种。
上述药用辅料中可加入能调节pH值至4～6的柠檬酸、马来酸、琥珀酸、苹果酸等有机酸中的一种或几种，以便于适应阴道内环境，同时有效发挥药物作用。
上述药用辅料中还可加入肉桂油、青蒿油、艾蒿油、山苍子油等天然芳香植物挥发油或其有效单体中的一种或几种，以便用它们化浊。
本发明提供的青蒿素制剂用常规的制备方法制得。
本发明提供的青蒿素制剂对妇科霉菌性阴道炎、滴虫等病原菌有良好的抑制或杀灭作用。
本发明所述青蒿素制剂中的主要活性成分青蒿素或其衍生物，经研究证实，对滴虫和深部霉菌(如白色念珠菌等)具有抑制或杀灭作用，加之使用了柠檬酸等有机酸来调整药物的pH值，使之在病灶所处的酸性环境中也能充分发挥其药效，由于还可配入适宜的芳香剂，使药物更具芳香化浊的效果，同时药物散发出来的宜人清香，适应了人体生理的人性化设计。另本发明还具有内在质量优秀、外在质量宜人等特点，从而可大大提高患者使用的依从性，进而为提高疗效乃至根治疾病打下基础。
实施例1
青蒿素羟丙环糊精软膏(40支)，处方：
青蒿素 0.8g 丙环糊精 40g
聚异丁烯酸甘油酯 10g 乙醇 40g
丙二醇 60g 柠檬酸 2g
肉桂油 2ml 蒸馏水加至 1000g
制备：先将青蒿素和羟丙环糊精混匀后，进行气流粉碎超细化(粒径＜10μm)，同时完成包结工作。然后与柠檬酸加入500ml蒸馏水中制得水相。余物用乙醇丙二醇溶解得油相，合并，补加蒸馏水至1000g，进行乳化，分装，即得青蒿素软膏每支25g：20mg的成品。
实施例2
蒿甲醚微囊片(1000粒)，处方：
蒿甲醚 80g 乙基纤维素 150g
羟丙甲纤维素 50g PEG-10000 2g
柠檬酸 6g
制备：将上述处方量的各物质溶于2200ml异丙醇溶剂中，选择进口温度60～70℃，出口温度50～55℃，经喷雾干燥即得蒿甲醚的微囊，以片重0.29压片，可得1000片含量为80mg蒿甲醚微囊片
实施例3
青蒿琥酯异型片(1000片)，处方：
青蒿琥酯 160g 羧甲基纤维素 10g
羟丙甲纤维素 20g 可溶性淀粉 200g
PEG-10000 2g 苹果酸 4g
肉桂油 2ml 青蒿油 1ml
制备：将处方量的各物质混合、打粉、制粒、干燥，以片重0.399压异型片，可得1000片含量为160mg青蒿琥酯异型片
实施例4 双氢青蒿素栓剂(1000支)，处方：
双氢青蒿素 200g 明胶 600g
甘油 2100g PEG-10000 2g
马来酸 6g 山苍子油 1ml
水 300g
制备：将处方量的双氢青蒿素、马来酸和山苍子油溶于甘油，将明胶和PEG-10000溶于水，于50～55℃水浴中加热溶解，混合两个溶液，加入每栓3.2g栓剂模型中成型，得每个栓剂含双氢青蒿素200mg得阴道用栓剂。
实施例5
蒿乙醚阴道用软胶囊(1000粒)，处方：
蒿乙醚 100g 月见草油 400g
红花油 200g 维生素E 50g
艾蒿油 1ml
制备：将月见草油和红花油混合，依次加入维生素E、艾蒿油、马来酸、蒿乙醚，搅拌溶解，按每粒771mg内容物用阴道用软胶囊模来加工处理，即得蒿乙醚阴道用软胶囊1000粒、规格为100mg。
实施例6
蒿甲醚软膏(100支)，处方：
蒿甲醚 100.0g 丙二醇 150.0g
聚乙二醇 450.0g 羧乙烯聚合物 50.0g
甘油 100.0g 三乙醇胺 10.0g
肉桂油 5.0ml 精制水 285.0g
制备：先将蒿甲醚和肉桂油溶于丙二醇和聚乙二醇的混合物中，加入羧乙烯聚合物的水膨胀液及甘油后，再加入三乙醇胺，搅拌制成软膏，得1150g，分装成每支11.5g的软管包装，可得100支蒿甲醚软膏，规格为1g蒿甲醚/支。
药效学研究：
1、对滴虫病的作用和止痒效果的观察
药物：实施例6蒿甲醚软膏甲硝唑片
病人：医院确诊的门诊病人8人，分两组。
试验：一组病人(试验组)4名用实施例6制备的蒿甲醚软膏；另一组病人(对照组)4名用甲硝唑片。用药方法为早晚各一次，常规清洗外阴后，阴道内给药，7天为一疗程。一个疗程后用[悬滴法]化验检查。并询问病人止痒效果。
结果：试验组4名病人检查均为阴性，病人主观感觉止痒效果明显；对照组3名人为阴性，病人主观感觉有一定的止痒效果。表明蒿甲醚软膏对阴道滴虫病具有治疗作用，且对直接的表现症状——瘙痒效果明显。
2、对真菌的作用
药物：实施例3青蒿琥酯异型片制霉菌素
菌种：白色念球菌，试验用第二代新鲜培养物，由中国科学院微生物研究所提供。
培养基：自制备用。
液体试管法：
取灭菌小试管若干支，用培养基稀释被试药使其浓度为0.5、0.25、0.125、0.06g/ml，每管加入1毫升，再加入200倍稀释的18小时真菌培养物0.1ml，于37℃培养18小时后观察有无真菌生长。真菌不生长的最高药物稀释度为该药的最低抑菌浓度。结果如下：
| 样品 | 浓度(g/ml) | ||||
| 0.5 | 0.25 | 0.125 | 0.06 | 0 | |
| 空白青蒿制霉 | -- | -- | +- | +++ | +++ |
注：表中“-”表示细菌没有生长，即有抑菌作用；“+”表示细菌已有生长，即表示没有抑菌作用。
结果表明：该制剂对白色念珠菌有较好的抑制或杀灭作用，作用机理有待进一步研究。
3、皮肤黏膜刺激性试验
药物：实施例5制得的蒿乙醚阴道用软胶囊
动物：大白兔雌性4只，体重2.1±0.5kg。
方法：动物分为对照组和给药组，每组两只，将药液0.2ml注入兔子阴道内，观察小时局部及全身反应，随后处死动物，取出阴道黏膜进行病理学检查。
结果：观察结果表明用药后阴道组织无充血、红肿等黏膜受到刺激的现象。
1、一种治疗妇科疾病的青蒿素制剂，其特征在于由下列组分：
青蒿素 0.8g 丙环糊精 40g
聚异丁烯酸甘油酯 10g 乙醇 40g
丙二醇 60g 柠檬酸 2g
肉桂油 2ml 蒸馏水加至 1000g
制成每支含青蒿素20mg的青蒿素软膏40支。
2、一种治疗妇科疾病的青蒿素制剂，其特征在于由下列组分：
蒿甲醚 80g 基纤维素 150g
羟丙甲纤维素 50g PEG-10000 2g
柠檬酸 6g
制成每片含青蒿素80mg的蒿甲醚微囊1000片。
3、一种治疗妇科疾病的青蒿素制剂，其特征在于由下列组分：
青蒿琥酯 160g 羧甲基纤维素 10g
羟丙甲纤维素 20g 可溶性淀粉 200g
PEG-10000 2g 苹果酸 4g
肉桂油 2ml 青蒿油 1ml
制成每片含青蒿素160mg的青蒿琥酯异型片1000片。
4、一种治疗妇科疾病的青蒿素制剂，其特征在于由下列组分：
双氢青蒿素 200g 明胶 600g
甘油 2100g PEG-10000 2g
马来酸 6g 山苍子油 1ml
水 300g
制成每支含青蒿素200mg的双氢青蒿素栓1000支。
5、一种治疗妇科疾病的青蒿素制剂，其特征在于由下列组分：
蒿乙醚 100g 月见草油 400g
红花油 200g 维生素E 50g
艾蒿油 1ml
制成1000粒蒿乙醚阴道用软胶囊。
6、一种治疗妇科疾病的青蒿素制剂，其特征在于由下列组分：
蒿甲醚 100.0g 丙二醇 150.0g
聚乙二醇 450.0g 羧乙烯聚合物 50.0g
甘油 100.0g 三乙醇胺 10.0g
肉桂油 5.0ml 精制水 285.0g
制成100支蒿甲醚软膏。
Arteannuin preparation for treating gynecopathy
The present invention provides an arteannuin preparation used for curing gynecopathy, which is a medical acceptable preparation prepared from a medical adjuvant and a medical effective component. The present invention is characterized in that the medical effective component is arteannuin or a derivative thereof, and each smallest preparation unit contains 0.02 to 1.0g of arteannuin or derivative thereof, so that the arteannuin preparation has a favorable inhibitory function or a killing function on gynecological colpomycosis, trichomonad and other pathogens; additionally, the medical pH value is adjusted by organic acid, such as citric acid, etc., to make the medical effect fully exerted in the acid environment of focus; a suitable flavoring agent is matched to make the medicine have favorable effect of eliminating turbid pathogen with aromatics, and the hospitable delicate fragrance given forth from the medicine adapts to the humanization design of the human body physiology. In addition, the present invention has the characteristics of excellent inner quality, hospitable external quality, etc., so that the dependence of the patient can be greatly improved to supply the basis for increasing the curative effect or even eradicating the disease.
The arteannuin preparation of treatment gynaecopathia
Technical field
The present invention relates to a kind of arteannuin pharmaceutical preparation for the treatment of gynaecopathia, belong to the technical field of medicine.
Background technology
Gynaecopathia is the able-bodied disease of serious harm women, and the most commonly trichomonal vaginitis, colpitis mycotica etc. in gynaecopathia, this main and women special environments of reproductive tract outward are relevant.Herba Artemisiae Annuae is a kind of conventional Chinese medicine, and it is used as medicine and sees " 52 Bingfang " that No. three tomb of Han dynasty in Mawangdui are unearthed the earliest.Herba Artemisiae Annuae (Artemisia annua L), bitter in the mouth cold in nature is commonly used to heat clearing away, expelling summer-heat.Compendium of Material Medica record according to Li Shizhen (1518-1593 A.D.): Herba Artemisiae Annuae cures mainly dermatosis, epistaxis, hemorrhoidal hemorrhage, malaria, deficiency-heat etc.From nineteen seventies, the Chinese science man first from Herba Artemisiae Annuae separation and Extraction gone out since new antimalarial agent-arteannuin, arteannuin has caused the extensive concern of the world of medicine.The arteannuin and the derivant thereof of having gone on the market at present have: arteannuin, Artemether, artesunate, dihydroarteannuin, arteether, the acid of Artemisia ether woods etc., and all also constantly studying the new derivant of arteannuin both at home and abroad.Application and the research in field of medicaments of arteannuin and derivant thereof had report, but did not then appear in the newspapers with application in the research of gynaecopathia such as trichomonal vaginitis, colpitis mycotica etc.
Summary of the invention
Purpose of the present invention aims to provide the arteannuin pharmaceutical preparation of a kind of steady quality, safety is good, curative effect is superior treatment gynaecopathia.
The present invention in conjunction with the research of the present invention to artemisine pharmacy drug effect toxicity, is the preparation that act directly on focus with drug development according to the characteristics of gynaecopathia.
The present invention realizes by following technical proposal: it makes acceptable preparation by pharmaceutic adjuvant and effective ingredient, it is characterized in that effective ingredient is the arteannuin or derivatives thereof, and each minimum preparation unit contains arteannuin or derivatives thereof 0.02g-1.0g.
Described pharmaceutic adjuvant is one or more in hydroxypropyl cyclodextrin, polyisobutylene acid glyceride, ethanol, propylene glycol, ethyl cellulose, hypromellose, PEG-10000, hydroxy methocel, soluble starch, gelatin, glycerol, Radix Oenotherae erythrosepalae oil, Oleum Arachidis hypogaeae semen, vitamin E, Polyethylene Glycol, hydroxyalkyl vinyl polymer, the triethanolamine.
Can add in the organic acid such as the citric acid that can regulate pH value to 4～6, maleic acid, succinic acid, malic acid one or more in the above-mentioned pharmaceutic adjuvant, so that adapt to the intravaginal environment, effective performance drug effect simultaneously.
Also can add in Oleum Cinnamomi, Herba Artemisiae Annuae oil, mugwort oil, Fructus Litseae wet goods natural aromatic plant volatile oil or its effective monomer one or more in the above-mentioned pharmaceutic adjuvant, so that change turbid with their.
Arteannuin preparation provided by the invention makes with conventional preparation method.
Arteannuin preparation provided by the invention has good inhibition or killing action to pathogen such as gynecological's colpitis mycotica, infusorian.
Main active arteannuin or derivatives thereof in the arteannuin preparation of the present invention, confirm after deliberation, infusorian and deep mycete (as Candida albicans etc.) are had and suppress or killing action, used organic acid such as citric acid to adjust the pH value of medicine in addition, make it in the residing sour environment of focus, also can give full play to its drug effect, owing to also can allocate suitable aromatic into, make medicine have more the effect of eliminating turbid pathogen with aromatics, the pleasant delicate fragrance that the while medicine comes out has adapted to the human oriented design of Human Physiology.The present invention also has characteristics such as inherent quality is outstanding, external quality is pleasant in addition, thereby can improve the compliance that the patient uses greatly, and then lays the first stone for improving curative effect and even radical curing of disease.
Embodiment 1
Arteannuin hydroxypropyl cyclodextrin ointment (40), prescription:
The arteannuin 0.8g third cyclodextrin 40g
Polyisobutylene acid glyceride 10g ethanol 40g
Propylene glycol 60g citric acid 2g
Oleum Cinnamomi 2ml distilled water adds to 1000g
Preparation: earlier with behind arteannuin and the hydroxypropyl cyclodextrin mixing, carry out comminution by gas stream super-refinement (particle diameter＜10 μ m), finish inclusion work simultaneously.Add in the 500ml distilled water with citric acid then and make water.Excess with the ethanol propylene glycol dissolve oil phase, merge, add distilled water to 1000g, carry out emulsifying, packing promptly gets the finished product of every 25g:20mg of arteannuin ointment.
Embodiment 2
Artemether microencapsule tablet (1000), prescription:
Artemether 80g ethyl cellulose 150g
Hypromellose 50g PEG-10000 2g
Citric acid 6g
Preparation: each material of above-mentioned recipe quantity is dissolved in the 2200ml isopropanol solvent, select 60～70 ℃ of inlet temperatures, 50～55 ℃ of outlet temperatures, the spray-dried microcapsule that promptly gets Artemether, weigh 0.29 tabletting with sheet, can get 1000 content is 80mg Artemether microencapsule tablet
Embodiment 3
Artesunate special-shaped tablets (1000), prescription:
Artesunate 160g carboxymethyl cellulose 10g
Hypromellose 20g soluble starch 200g
PEG-10000 2g malic acid 4g
Oleum Cinnamomi 2ml Herba Artemisiae Annuae oil 1ml
Preparation: each material of recipe quantity is mixed, beats powder, granulation, drying, weigh 0.399 with sheet and press special-shaped tablets, can get 1000 content is 160mg artesunate special-shaped tablets
Embodiment 4 bi-hydrogen arteannuin suppositories (1000), prescription:
Dihydroarteannuin 200g gelatin 600g
Glycerol 2100g PEG-10000 2g
Maleic acid 6g litsea cubeba oil 1ml
Water 300g
Preparation: dihydroarteannuin, maleic acid and the litsea cubeba oil of recipe quantity are dissolved in glycerol, gelatin and PEG-10000 is water-soluble, heating for dissolving in 50～55 ℃ of water-baths, mix two solution, add molding in every bolt 3.2g suppository mould, each suppository contains dihydroarteannuin 200mg and gets vaginal suppository.
Embodiment 5
Arteether soft capsule for vagina (1000), prescription:
Arteether 100g Radix Oenotherae erythrosepalae oil 400g
Safflower oil 200g vitamin E 50g
Mugwort oil 1ml
Preparation: Radix Oenotherae erythrosepalae oil and Flos Carthami oil is mixed, add vitamin E, mugwort oil, maleic acid, arteether successively, stirring and dissolving is come processed by every 771mg content with the soft capsule for vagina mould, promptly gets 1000 of arteether soft capsule for vagina, specification is 100mg.
Embodiment 6
Artemether ointment (100), prescription:
Artemether 100.0g propylene glycol 150.0g
Polyethylene Glycol 450.0g carboxy vinyl polymer 50.0g
Glycerol 100.0g triethanolamine 10.0g
Oleum Cinnamomi 5.0ml Purified Water 285.0g
Preparation: earlier Artemether and Oleum Cinnamomi are dissolved in the mixture of propylene glycol and Polyethylene Glycol, after adding the water inflation fluid and glycerol of carboxy vinyl polymer, add triethanolamine again, ointment is made in stirring, get 1150g, be distributed into the hose packing of every 11.5g, can get 100 Artemether ointment, specification be the 1g Artemether/.
Pharmacodynamic study:
1, to the effect of trichomoniasis and the observation of antipruritic effect
Medicine: embodiment 6 Artemether ointment Metronidazole Tablets
Patient: outpatient 8 people that hospital makes a definite diagnosis, divide two groups.
Test: 4 Artemether ointment of one group of patient (test group) with embodiment 6 preparations; Another group patient (matched group) 4 used Metronidazole Tablet.Administrated method is sooner or later respectively once, behind the conventional cleaning pudendum, and intravaginal administration, 7 days is a course of treatment.Use [sessile drop method] laboratory examination after the course of treatment.And inquiry patient antipruritic effect.
The result: 4 patients of test group check all negative, and patient's subjective sensation antipruritic effect is obvious; 3 famous persons are negative for matched group, and patient's subjective sensation has certain antipruritic effect.Show that Artemether ointment has therapeutical effect to trichomonal vaginitis, and to direct reveal any symptoms---the pruritus effect is obvious.
2, to the effect of fungus
Medicine: embodiment 3 artesunate special-shaped tablets nystatins
Strain: Candida albicans, test is provided by Institute of Microorganism, Academia Sinica with second filial generation fresh cultured thing.
Culture medium: make by oneself standby.
Liquid tube method:
Get some of sterilization small test tubes, made by reagent with culture medium dilution that its concentration is 0.5,0.25,0.125,0.06g/ml, every pipe adds 1 milliliter, adds 18 hours fungal cultures 0.1ml of 200 times of dilutions again, observes after 18 hours in 37 ℃ of cultivations to have or not conk.The highest drug dilution degree that fungus does not grow is the minimum inhibitory concentration of this medicine.The result is as follows:
| Sample | Concentration (g/ml) | ||||
| 0.5 | 0.25 | 0.125 | 0.06 | 0 | |
| Blank Herba Artemisiae Annuae system is mould | - - | - - | + - | ++ + | +++ |
Annotate: not growth of "-" expression antibacterial in the table promptly has bacteriostasis; The existing growth of "+" expression antibacterial, i.e. expression does not have bacteriostasis.
The result shows: said preparation has inhibition or killing action preferably to Candida albicans, and the mechanism of action remains further to be studied.
3, skin mucosa irritation test
The arteether soft capsule for vagina that medicine: embodiment 5 makes
Animal: female 4 of White Rabbit, body weight 2.1 ± 0.5kg.
Method: animal is divided into matched group and administration group, and two every group, medicinal liquid 0.2ml is injected the rabbit intravaginal, observe hour part and general reaction, put to death animal subsequently, take out vaginal mucosa and carry out pathological examination.
The result: vagina tissue did not have the phenomenon that mucosas such as hyperemia, redness are upset after observed result showed medication.
1, a kind of arteannuin preparation for the treatment of gynaecopathia is characterized in that by following component:
The arteannuin 0.8g third cyclodextrin 40g
Polyisobutylene acid glyceride 10g ethanol 40g
Propylene glycol 60g citric acid 2g
Oleum Cinnamomi 2ml distilled water adds to 1000g
Make 40 of every arteannuin ointment that contains arteannuin 20mg.
2, a kind of arteannuin preparation for the treatment of gynaecopathia is characterized in that by following component:
Artemether 80g base cellulose 150g
Hypromellose 50g PEG-10000 2g
Citric acid 6g
Make 1000 of every Artemether microcapsules that contains arteannuin 80mg.
3, a kind of arteannuin preparation for the treatment of gynaecopathia is characterized in that by following component:
Artesunate 160g carboxymethyl cellulose 10g
Hypromellose 20g soluble starch 200g
PEG-10000 2g malic acid 4g
Oleum Cinnamomi 2ml Herba Artemisiae Annuae oil 1ml
Make 1000 of every artesunate special-shaped tablets that contains arteannuin 160mg.
4, a kind of arteannuin preparation for the treatment of gynaecopathia is characterized in that by following component:
Dihydroarteannuin 200g gelatin 600g
Glycerol 2100g PEG-10000 2g
Maleic acid 6g litsea cubeba oil 1ml
Water 300g
Make 1000 on every dihydroarteannuin bolt that contains arteannuin 200mg.
5, a kind of arteannuin preparation for the treatment of gynaecopathia is characterized in that by following component:
Arteether 100g Radix Oenotherae erythrosepalae oil 400g
Safflower oil 200g vitamin E 50g
Mugwort oil 1ml
Make 1000 arteether soft capsule for vagina.
6, a kind of arteannuin preparation for the treatment of gynaecopathia is characterized in that by following component:
Artemether 100.0g propylene glycol 150.0g
Polyethylene Glycol 450.0g carboxy vinyl polymer 50.0g
Glycerol 100.0g triethanolamine 10.0g
Oleum Cinnamomi 5.0ml Purified Water 285.0g
Make 100 Artemether ointment.
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