绿色奇迹：青蒿素的多维商业化探索|Green Miracle: Exploring the Multifaceted Commercialization of Artemisinin

北卡理工大学的 Pamela Whethers 博士在这次疫情期间用体外新冠感染的细胞株试验,证明艾叶热泡后溶液比单纯的青蒿素有更强的抗病毒性，表明植物中其它不明成分的作用。

非洲蒿不含青蒿素，抗新冠作用是青蒿素的几十倍以上。

伍斯特理工学院 Pamela Weathers 教授专栏 https://www.wpi.edu/people/faculty/weathers

青蒿热水提取物在体外对 Covid-19 变体（包括 delta）显示出有效的活性  https://doi.org/10.1016/j.jep.2021.114797

实施例3 青蒿素及其假体治疗脱发的作用

一、材料 1.1青蒿素及其假固体分散体

制备同实施例1；使用时用无水乙醇配成含有青蒿素及其近似20mg/100ml浓度，每次喷雾脱发处均干燥为溶液，每天早午晚各观测1次。

二、方法与结果 一批全头性圆形脱发患者80例，其中男性53例，女性47例，年龄40岁至65岁，

试验90天，生发行硬发者48例，生发行硬发浓密者32例，

试验180例天，生发生出硬发者63例，生发出硬发浓密者55例，总有效率93％，显效率78％，无效率7％，表明青蒿素及其固体分散体治疗脱发的作用。

https://patents.google.com/patent/CN106333945A/zh

基于上述信息，青蒿素及其提取物在抗新冠病毒和治疗脱发方面表现出显著的潜力。商业化思路可以包括以下几个方面：

医药领域：

抗病毒药物研发：基于 Pamela Whethers 博士的研究，青蒿素及其提取物在体外对 Covid-19 变体显示出有效的活性。商业化思路可以围绕这一发现展开，推动进一步的临床研究，争取将青蒿素纳入抗病毒药物的研发。

脱发治疗产品：根据实施例3的信息，青蒿素及其固体分散体在治疗脱发方面表现出良好的效果。商业化思路可以包括研发相关的药物或医疗产品，例如洗发水、喷雾剂等，以满足脱发患者的需求。

保健品领域：

抗氧化保健品：考虑将青蒿素及其提取物应用于抗氧化保健品，因为抗氧化剂对健康有益，可用于提高免疫力和预防疾病。

头发保健产品：基于脱发治疗的成功实例，可以开发面向头发健康的保健产品，满足消费者对于美容和健康的需求。

农业领域：

青蒿素的农业用途：考虑将青蒿素应用于植物保护，以提高农作物的抗病虫能力，增加农业产值。

有机农业：推动有机青蒿的种植，以生产更纯净、无农药残留的原材料，满足对有机产品的市场需求。

科研合作与专利保护：

与研究机构合作：建立合作关系，共同推动青蒿素的研究和开发，加速产品上市。

专利保护：确保对相关技术的专利保护，以保障商业利益和市场竞争优势。

市场推广和教育：

科普宣传：通过科普宣传活动向公众传递青蒿素的研究成果，提高产品认知度。

医学专业推广：与医疗机构和专业人士合作，推广青蒿素的医学应用，提升在医学领域的声誉。

国际市场拓展：

进军国际市场：基于青蒿素在抗病毒和脱发治疗领域的潜力，考虑拓展国际市场，与国际企业和研究机构展开合作。

这些商业化思路可以根据实际情况进行调整和细化，但整体上旨在充分发挥青蒿素及其提取物在医药、保健品和农业等领域的潜在价值。

Dr. Pamela Whethers from North Carolina State University conducted experiments during this pandemic using in vitro COVID-19 infected cell lines, demonstrating that the solution obtained after hot-infusing Artemisia annua leaves exhibits stronger antiviral properties compared to pure artemisinin. This suggests the involvement of other unidentified components in plant action.

African sweet wormwood does not contain artemisinin, yet its anti-COVID effects surpass those of artemisinin by several times.

Professor Pamela Weathers from Worcester Polytechnic Institute provides insights in her column: https://www.wpi.edu/people/faculty/weathers

Hot water extract of Artemisia annua demonstrates effective activity against COVID-19 variants (including delta) in vitro: https://doi.org/10.1016/j.jep.2021.114797

Example 3: The effects of artemisinin and its pseudo-solid dispersion in treating hair loss

I. Materials 1.1 Artemisinin and its pseudo-solid dispersion (prepared as in Example 1; when in use, dissolve in anhydrous ethanol to achieve a concentration of approximately 20mg/100ml. Spray the solution on the area of hair loss, allowing it to dry each time. Observe morning, noon, and night daily.

II. Methods and Results A batch of 80 patients with total circular hair loss, including 53 males and 47 females aged 40 to 65, underwent a 90-day trial. Among them, 48 showed hair regrowth with increased firmness, and 32 showed thickening of the regrown hair. In a 180-day trial, 63 patients exhibited firm hair regrowth, and 55 showed thickening of the regrown hair. The overall effective rate was 93%, with a notable effect rate of 78% and an ineffectiveness rate of 7%, indicating the efficacy of artemisinin and its pseudo-solid dispersion in treating hair loss.

https://patents.google.com/patent/CN106333945A/en

Based on the above information, artemisinin and its extracts demonstrate significant potential in combating the novel coronavirus and treating hair loss. The commercialization strategy encompasses various sectors:

Medical Field:

Antiviral Drug Development: Building on Dr. Pamela Whethers' research, artemisinin and its extracts exhibit effective activity against COVID-19 variants in vitro. The commercialization strategy involves further clinical research to integrate artemisinin into antiviral drug development.

Hair Loss Treatment Products: Leveraging the positive outcomes from Example 3, the strategy includes developing related drugs or medical products, such as shampoos and sprays, to meet the needs of individuals experiencing hair loss.

Health Products:

Antioxidant Health Products: Considering the application of artemisinin and its extracts in antioxidant health products due to the beneficial effects of antioxidants on health, promoting immunity, and preventing diseases.

Hair Care Products: Based on successful instances in treating hair loss, the strategy involves developing health products aimed at promoting hair health, meeting consumer demands for beauty and health.

Agricultural Field:

Artemisinin's Agricultural Applications: Considering the application of artemisinin in plant protection to enhance crops' resistance to diseases and pests, thereby increasing agricultural yields.

Organic Farming: Advocating for the cultivation of organic Artemisia annua to produce purer, pesticide-free raw materials, meeting the market demand for organic products.

Research Collaboration and Patent Protection:

Collaboration with Research Institutions: Establishing collaborative relationships to accelerate research and development of artemisinin, expediting product launch.

Patent Protection: Ensuring the protection of relevant technologies through patents to safeguard commercial interests and maintain a competitive advantage in the market.

Market Promotion and Education:

Public Awareness Campaigns: Conducting public awareness campaigns to disseminate the research findings on artemisinin, increasing product awareness.

Medical Professional Promotion: Collaborating with medical institutions and professionals to promote the medical applications of artemisinin, enhancing its reputation in the medical field.

International Market Expansion:

Venturing into International Markets: Capitalizing on the potential of artemisinin in antiviral and hair loss treatment, considering expanding into international markets and collaborating with international companies and research institutions.

These commercialization strategies can be adjusted and refined based on the actual situation, but overall, they aim to fully exploit the potential value of artemisinin and its extracts in the fields of medicine, health products, and agriculture.