Roger

Shantisays: NOVEMBER 17, 2019 AT 2:50 AM Hi D, I appreciate you sharing your experience, the details are important, so definitely not too much detail. 11 to 7 is a pretty big drop in hemoglobin so we will monitor it closely if we do this therapy. We won’t go above 110mg artesunate in a push, which is the dose suggested for IV push malarial treatment, if we go higher in dose I will use a drip. I’ll also re-read the IVC post with info on iron chelation. My husband’s serum iron and ferritin tend to be at the low end of normal already. Warmly, Shanti PS This artemisia post is so comprehensive and useful, it is amazing to have this information pulled together in one place! 嗨 D， 我感谢你分享你的经验，细节很重要，所以绝对不会太多。从11下降到7是血红蛋白相当大的下降，所以如果我们进行这种疗法，我们会密切监测。如果我们使用更高剂量，我将使用滴注，我们不会超过110毫克的青蒿素。此剂量是用于治疗疟疾的静脉注射的建议剂量。我还会重新阅读关于铁螯合的IVC帖子。我丈夫的血清铁和铁蛋白通常已经处于正常范围的低端。 热情地， Shanti PS 这篇青蒿素文章内容丰富、实用，将这些信息集合在一起真是太神奇了！

Danielsays: NOVEMBER 17, 2019 AT 12:23 AM Hi Shanti, The drop in hemoglobin was gradual, from around 11 (normal range 11,9-14,6 g/dl) to around 7, during about one month (February to March 2014). After that we switched to DCA, Na Bic and Vitamin B17 (all intravenous) for 3 months and haemoglobin recovered so that in June 2014 was in a normal range, i.e. 13. I can not connect 100% the drop of hemoglobin with combo of Vit C and Arte, as there is one more point that I have to make: just after 2 months from surgery, in Jan 2014, there was a recurrence of about 4cm at the adrenal gland location. In June 2014, that became half (and latter was gone). Adrenal tumors are growing very fast, so another possibility is that the combo Vit C and Arte was not effective for us (and the drop of hemoglobin was due to fast growth of the tumor) and the next combo of DCA+B17+Na Bic was effective. However, because of the relative fast recovery of hemoglobin after switching to DCA+B17+Na Bic, I suspect it was Vit C +Arte too strong. Latter, we did Vit C and Arte but never combined and we never had this issue again. I hope these are not too many details, and it helps. I do not know anyone who did Arte bolus as you intend to do. If going for bolus, I would do it step by step, first with a smaller dose. Kind regards, Daniel 你好Shanti， 血红蛋白下降是逐渐的，从大约11（正常范围为11.9-14.6 g/dl）下降到约7，在大约一个月内（2014年2月至3月）。之后我们切换到DCA、Na Bic和维生素B17（全部静脉给药），进行了3个月的治疗，血红蛋白恢复到了正常范围，即13。我无法100%确定血红蛋白下降与维C和青蒿素的结合有关，因为我还有一个要点要说明：就在手术后的2个月后，即2014年1月，肾上腺位置复发了约4厘米的肿瘤。到了2014年6月，它变成了一半（后来完全消失了）。肾上腺肿瘤生长非常快，所以另一个可能性是维C和青蒿素对我们来说不起作用（血红蛋白下降是肿瘤快速生长的结果），而下一个组合的DCA+B17+Na Bic有效。但是，由于切换到DCA+B17+Na Bic后血红蛋白的相对快速恢复，我怀疑是维C+青蒿素太强了。后来，我们分别使用了维C和青蒿素，但从未结合使用，并且再也没有出现这个问题。 我不认识任何人进行过您打算进行的青蒿素注射。如果要进行注射，我建议先使用较小剂量。 祝一切顺利， 丹尼尔

Shantisays: NOVEMBER 16, 2019 AT 7:17 PM Here is the info on IV push administration: https://www.cdc.gov/malaria/resources/pdf/artesunate/Artesunate_protocol_12_19_2016.pdf 以下是有关静脉推注给药的信息：https://www.cdc.gov/malaria/resources/pdf/artesunate/Artesunate_protocol_12_19_2016.pdf

Shantisays: NOVEMBER 16, 2019 AT 7:16 PM Hi D and All- We would like to add some IV Artesunate to our weekly IVC. In a couple weeks my husband wants to do a week of daily IVC and I’d also like to use the IV Artesunate 3 times during that week. The suggested IV dose as documented by D is 300mg/day. I have access to 120mg Artesunate vials. My question is this: I noticed that for malaria treatment the Artesunate is either given as an IM injection or as an IV push ( but for the IV it is not typically given at a dose of 300mg in a single push for someone of my husband’s weight). We prefer to do a push rather than add more time and fluid on to the already lengthy IVC. I’m thinking of pushing in half of it before the IVC and the other half after the IVC. Does anyone see any potential issues with this? D, you have mentioned a drop in hemoglobin with artesunate/IVC combo, do you recall how much of a drop? My husbands tends to be just under or just over the normal range. Thank you! 大家好， 我们想在每周的IVC治疗中加入一些IV Artesunate。在几周后，我丈夫希望进行一周的每日IVC治疗，而我也想在那一周中使用IV Artesunate进行3次治疗。根据D的建议，IV Artesunate的建议剂量为每天300毫克。我可以获得120毫克的Artesunate小瓶。 我的问题是这样的：我注意到对于疟疾治疗，Artesunate通常是作为肌肉注射或者静脉推注（但对于IV推注，不会单次推注300毫克的剂量给体重与我丈夫相当的人）。我们更倾向于进行推注，而不是为了给予已经很长的IVC治疗增加更多的时间和液体。我考虑在IVC之前推注一半，IVC之后再推注另一半。有人看到这种做法可能存在的问题吗？ D，你提到了使用artesunate/IVC组合可能会导致血红蛋白下降，你还记得下降的幅度吗？我丈夫的血红蛋白水平通常处于正常范围的下限或上限。 谢谢你们！ 以上名词的翻译可能是 ： IV Artesunate 静脉注射青蒿琥酯 Intravenous Vitamin C 静脉注射维生素 C

kapil.agrawalkapilsays: JULY 22, 2019 AT 8:27 AM Very helpful Shanti! I could not have asked for a more clear explanation. Best wishes for your husband! 很有帮助，Shanti！我无法要求更清晰的解释了。祝你丈夫一切顺利！

Shantisays: JULY 15, 2019 AT 9:14 PM Hi Kapil, I know that I am not Daniel, but I also know he is traveling with limited availability, so I thought I would attempt to answer your question. You may find some of your answer here in Daniel’s earlier post: https://www.cancertreatmentsresearch.com/artemisia-annua-its-extract-artemisinin/#comment-5396 and also in the “Mechanism” section of the blog post itself. Basically, you want to keep the artemisinin out of contact with iron in the circulation. If the artemisinin comes into contact with iron in the circulation, there will be a free radical burst, but the artemisinin will be destroyed in the process. You want this to happen inside of the cancer cell, not before. In Daniel’s earlier post, he states that he believes cancer cells likely have enough concentrated iron without the need to take iron, so taking an iron chelator would clear iron from circulation, allowing the artemisinin to reach the tumor. Regarding TM, we almost used Tetrathiomolybdate(TM), and went as far as getting a prescription for it, but we opted not to use it at this time based on several factors related to my husband’s situation. TM depletes copper which is needed to produce RBCs and hemoglobin: https://en.wikipedia.org/wiki/Copper_deficiency. It may have some impact on iron absorption but it is not reported to cause iron deficiency. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417757/. The anemia induced by TM is purely copper induced. That being said, those who have iron deficiency to the extent that it has lowered their RBC/hemoglobin count should correct it before starting TM. Those who have very low RBC/hemoglobin and/or WBCs as a result of cancer treatments may not be able to use TM since TM can drop WBC and RBC count even further. When people are using TM, ceruloplasmin and a complete blood count are used to monitor, if WBCs drop too low, the treatment is temporarily halted until they increase again. I hope that helps! 你好 Kapil， 我知道我不是 Daniel，但我也知道他在旅途中，时间有限，所以我想尝试回答你的问题。你可能会在 Daniel 之前的帖子中找到一些答案：链接：https://www.cancertreatmentsresearch.com/artemisia-annua-its-extract-artemisinin/#comment-5396 ，以及博客文章本身的“机制”部分。基本上，你希望将青蒿素与循环中的铁隔离开。如果青蒿素与循环中的铁接触，将会产生自由基爆发，但在过程中青蒿素将被破坏。你希望这种情况发生在癌细胞内部，而不是之前。在 Daniel 之前的帖子中，他提到他相信癌细胞很可能有足够的浓缩铁，因此不需要额外补充铁，因此服用铁螯合剂可以清除循环中的铁，使青蒿素能够到达肿瘤。 关于 TM，我们几乎使用了四硫化钼(TM)，甚至已经拿到了处方，但我们基于我丈夫情况相关的几个因素选择了暂时不使用。TM 会耗尽铜，而铜是生成红细胞和血红蛋白所需的：链接 https://en.wikipedia.org/wiki/Copper_deficiency 它可能对铁的吸收产生一些影响，但没有报道称其导致铁缺乏：链接：https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417757/ TM 引起的贫血纯粹是铜引起的。也就是说，如果有人因铁缺乏而导致红细胞/血红蛋白计数降低，那么在开始使用 TM 之前应该纠正这种情况。那些由于癌症治疗导致红细胞/血红蛋白和/或白细胞计数非常低的人可能无法使用 TM，因为 TM 可以进一步降低白细胞和红细胞计数。使用 TM 时，铜蓝蛋白和完整的血细胞计数被用于监测，如果白细胞计数过低，治疗会暂时停止，直到再次增加。 希望这能帮到你！

johansays: JULY 16, 2019 AT 1:49 AM Hi, most of the success stories with the use of ART I’ve read about either use no iron or take iron at the beginning of the treatment. Here’s a study showing better anti-cancer potency for the ART+iron combination. https://pdfs.semanticscholar.org/be85/9d5230290fba9e5c408581362bb15dafb001.pdf 嗨，大部分我读到的青蒿素成功案例都没有使用铁，或者在治疗开始时服用铁。这里有一项研究显示青蒿素与铁结合具有更好的抗癌效果。 链接：https://pdfs.semanticscholar.org/be85/9d5230290fba9e5c408581362bb15dafb001.pdf

kapil.agrawalkapilsays: JULY 15, 2019 AT 3:35 AM Hi Daniel, As always this was an excellent article filled with lots of relevant info detailing all aspects of Artemisinia Annua. You mentioned that taking an Fe chelator prior to Artemisinin might be better to enhance efficacy of Artemisinin. WOuldn’t an Fe chelator be contra-indicated rather. May be I am missing something. Also, are there any interactions with Tetrathiomolybdate (which is a well known Copper Chelator but as one of its side effects can also lower Haemoglobin which is linked to potential drop in Fe). 嗨，Daniel， 像往常一样，这是一篇充满了大量相关信息的优秀文章，详细介绍了青蒿素的各个方面。你提到在服用青蒿素之前服用铁螯合剂可能会更好地增强青蒿素的功效。但是，铁螯合剂是否不推荐使用？也许我漏掉了什么。 此外，青蒿素与四硫代钼酸盐是否有任何相互作用（四硫代钼酸盐是一种众所周知的铜螯合剂，但其副作用之一可能会降低血红蛋白，这与潜在的铁降低有关）。

Atomsays: MAY 9, 2019 AT 10:56 PM Anyone has tried to use Artemisinin along with Gelum drops as it contains iron? This study shows enhancement of cytotoxicitiy of artemisinins towards cancer cells by ferrous iron https://www.sciencedirect.com/science/article/pii/S0891584904004940 有人尝试过将青蒿素与含铁的Gelum滴剂一起使用吗？这项研究显示了铁离子对青蒿素对癌细胞的细胞毒性增强效应。

captivitysays: JUNE 10, 2019 AT 12:18 AM Hello Katja , My son has recently diagnosed with Pancreatic Cancer I’m unfortunately I can’t afford purshasing Artesunate for him. Can you please donate the I.V. and the the Artesunate tablets for me ? 你好Katja， 我儿子最近被诊断患有胰腺癌，我很不幸不能负担购买Artesunate的费用。 你能否捐赠给我儿子注射用的Artesunate和Artesunate片剂？

Danielsays: MARCH 31, 2018 AT 8:31 PM Thank you so much for your kind offer to donate the Artesunate vials and the Hepalin capsules! If anyone is interested I will help them connect with you via e-mail. Kind regards, Daniel 非常感谢您慷慨捐赠青蒿素注射液和Hepalin胶囊！如果有人感兴趣，我会通过电子邮件帮助他们与您联系。谢谢，Daniel

Katjasays: MARCH 31, 2018 AT 6:33 PM Dear struggeling friends, as I developed a strong pancreatitis after a 14-day i.v. Treatement without a pause, I will give away for free my remaining artesunate-vials. Each 60mg. There are 54 left and 45 ampules with the needed sodium bicarbonate. The missing 9 can be bought easily in any pharmazie. Additionally there are 300 cpsules of Hepalin, 300 caps. Of Hepamether, 60 cps of Artemix and 120 caps. Of Hepamether bought from the above mentioned US-company http://www.hepalin.com all for free or giving a donation to the foundation here, would be grate. Hope, anyone can use it. Best whishes Katja 亲爱的朋友们，由于我在连续14天的静脉治疗后患上了严重的胰腺炎，我将免费赠送我剩下的青蒿素注射液。每瓶60毫克。剩下54瓶，还有45瓶所需的碳酸氢钠。另外缺失的9瓶可以在任何药房轻松购买到。此外，还有来自上述美国公司 http://www.hepalin.com 购买的300粒Hepalin胶囊，300粒Hepamether胶囊，60粒Artemix胶囊和120粒Hepamether胶囊，全部免费或者捐赠给这里的基金会，将不胜感激。希望有人能够用得到。最好的祝愿，Katja

Danielsays: MARCH 31, 2018 AT 8:24 PM Thanks a lot for your feedback, Shanti! Kind regards, Daniel 谢谢你的反馈，Shanti！祝一切顺利，Daniel

Shantisays: MARCH 31, 2018 AT 2:04 AM Hi Daniel- Excellent article! We used Artemisinin 500mg bid 1 week on and 1 week off for about 6 months and then stopped for 6 months. We are about to start it up again but will now change strategies to lower the Artemisinin dose and add in some of the whole plant. Thanks Again! Shanti说： 你好Daniel- 很棒的文章！我们曾经使用青蒿素500毫克，每天两次，连续1周，然后停药1周，大约持续了6个月，然后停药了6个月。我们现在准备再次开始，但将改变策略，降低青蒿素剂量，并加入一些全草。再次感谢！

Danielsays: DECEMBER 4, 2017 AT 11:07 AM Hi, I do not think this is a problem. Just that Super Arte is expected to be more effective because of the extra components it has inside. In any case, next to the Artemisinin capsule I would also add a capsule containing the whole plant of Arte Annua (as discussed in the post above). Kind regards, Daniel Daniel说： 你好，我认为这不是问题。只是超级青蒿素由于内含额外成分，预计会更有效。无论如何，在青蒿素胶囊旁边，我还会添加一个含有青蒿全草的胶囊（如上文所述）。祝好，Daniel

nasrindehghan10@gmail.comsays: DECEMBER 4, 2017 AT 10:55 AM Dear Daniel, what is the difference between artemisinin and super artemisinin? My sister (breast cancer stage 4) used 60 capsules of super artemisinin 2x/day (Nutricology), then I wronged to order Super artemisinin and ordered Artemisinin. I want to know, It’s not a problem to use Artemisinin instead of Super artemisinin? thanks Hi Daniel, 青蒿素和超级青蒿素之间有什么区别？ 我姐姐（乳腺癌第四期）每天使用了60粒超级青蒿素胶囊2次（Nutricology），然后我错误地订购了超级青蒿素，我订购了青蒿素。 我想知道，使用青蒿素代替超级青蒿素是否有问题？ 谢谢

Danielsays: NOVEMBER 29, 2017 AT 9:52 PM Hi Immanuel, It contains Sweet Wormwood (Leaves) oil in addition to Arte which I find it helpful. In order to understand more about Sweet Wormwood (Leaves) oil you may want to read this review article: Essential Oil of Artemisia annua L.: An Extraordinary Component with Numerous Antimicrobial Properties https://www.hindawi.com/journals/ecam/2014/159819/ There is a lot of research published on the bio-availability of Arte, e.g. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020007/ No it is not comparable with the IV form since that goes directly into the blood and will lead to higher plasma levels. I would use IV maybe 2-3 times/week for a few weeks cycle from time to time and during this time also the oral version. Or at least the days between the IV. Kind regards, Daniel 嗨，伊曼纽尔， 除了青蒿素外，它还含有甜蒿（叶子）油，我认为这很有帮助。为了更多地了解甜蒿（叶子）油，您可能想阅读这篇综述文章：《甜蒿（叶子）精油：具有众多抗菌特性的非凡成分》https://www.hindawi.com/journals/ecam/2014/159819/ 关于青蒿素的生物利用度，已经有很多研究发表了，例如https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020007/ 不，它与静脉注射形式不可比，因为那种方式可以直接进入血液，导致更高的血浆浓度。我建议使用静脉注射，也许每周2-3次，进行为期几周的循环治疗，并在此期间同时使用口服版本。或者至少在静脉注射之间的日子里使用口服版本。 亲切的问候， 丹尼尔

Danielsays: JUNE 1, 2022 AT 1:04 AM HI Nicole, Indeed, I woudl clearly not take them together for the reasons you mentioned. The other question is if it makes sense to take Iron supplements or not, since the cancer cells have already high amounts of iron. Some like the idea to use Iron in the Arte protocol, others not. I think that if we decided to take it, we better take it from foods instead of supplements. Kind regards, Daniel 嗨，尼科尔， 确实，出于你提到的原因，我肯定不会让它们一起服用。 另一个问题是是否有意义服用铁补充剂，因为癌细胞已经含有高浓度的铁。有些人喜欢在青蒿素方案中使用铁，而其他人则不喜欢。我认为，如果我们决定服用它，最好从食物中摄取而不是从补充剂中摄取。 亲切的问候， 丹尼尔

nnj925says: JUNE 1, 2022 AT 12:21 AM @Daniel did you say not to take the iron with ARt you mean specifically together right? I believe we are to Never take artemisinin with iron or shortly after the iron. The iron first needs to be circulated and distributed into the blood in small amounts and act as both an activator and as a trojan horse meaning that cancer cells will absorb some of it (which is what we want). The artemisinin will then be activated by the small amounts of iron in the blood and should target any cells that have absorbed high concentrations of iron (cancer cells). If you take the artemisinin right after the iron then the artemisinin will react in the stomach with the large supply of iron and be spent and not reach the cancer. Is this your thought as well? @Daniel 您是不是说不要与铁一起服用ARt，您指的是具体一起服用对吗？我相信我们永远不应该在铁之后或铁短时间内服用青蒿素。 铁首先需要以少量形式在血液中循环并分布，起到激活剂和特洛伊木马的作用，这意味着癌细胞将吸收其中的一些（这是我们想要的）。 然后，少量血液中的铁将激活青蒿素，并应该针对吸收了高浓度铁（癌细胞）的任何细胞。 如果您在铁后立即服用青蒿素，那么青蒿素将在胃中与大量的铁反应，然后消耗掉，无法到达癌细胞。这也是您的想法吗？

Danielsays: NOVEMBER 29, 2017 AT 9:37 PM Hi Immanuel, What I would specifically avoid is to take Arte at the same time with food or supplements containing Iron. As long as that is not the case, I do not see a reason for not combining. I would also avoid taking at the same time of the day strong antioxidants such as ALA or NAC. Kind regards, Daniel 亲爱的伊曼纽尔， 我会特别避免在同时服用含有铁质的食物或补充剂时服用Arte。只要不是这种情况，我认为组合使用是没有问题的。我也会避免在同一天同时服用强抗氧化剂，比如ALA或NAC。 祝好， 丹尼尔

immanuelbader@gmail.comsays: NOVEMBER 27, 2017 AT 11:22 AM I have another questions where i would really appreciate your thoughts on. What do you think of taking Sulforaphane, Curcumin and Artemisinin at the same time? Would this be a good combination? Thanks a lot, Immanuel Immanuel， 同时服用Sulforaphane、Curcumin和Artemisinin会怎么样？您对此有什么看法？这是否是一个好的组合？ 非常感谢， 伊曼纽尔

immanuelbader@gmail.comsays: NOVEMBER 25, 2017 AT 3:02 PM Hi Daniel, another question about nutricology super artemisinin. Do you know if this really contains pure artemisinin or is it also an extract from the plant like other manufacturers have? If its pure artemisinin, do you know anything about the bio availability when taking it oral? Is it in any way comparable with IV or IM? Or would you recommend IV or IM instead of oral intake? Thank you so much for all your effort, i really appreciate it! -Immanuel 嗨，丹尼尔， 关于Nutricology Super Artemisinin的另一个问题。您知道这是否真的含有纯青蒿素，还是像其他制造商一样是从植物中提取的？ 如果是纯青蒿素，您对口服时的生物利用度了解吗？它在口服时是否与静脉注射或肌肉注射有可比性？或者您是否建议口服而不是注射？ 非常感谢您的一切努力，我真的很感激！ - 伊曼纽尔

Danielsays: NOVEMBER 22, 2017 AT 10:39 PM Hi, I am not aware of any contraindication. Kind regards, Daniel 嗨，我不知道有任何禁忌。祝好，丹尼尔

marcosbomber901says: NOVEMBER 22, 2017 AT 10:00 PM Hi Daniel I am putting artesunate IV to my wife because he left 78 percent in test sensitivity,Do you know if there is any contraindication to mix it with DMSO,i can’t find anything about it. Thanks 11月22日 晚上10:00 嗨丹尼尔，我正在给我妻子注射青蒿素静脉注射，因为检测显示她的百分比在78％，您知道是否有任何禁忌症可以将其与DMSO混合使用，我找不到相关信息。谢谢

Danielsays: NOVEMBER 22, 2017 AT 9:23 PM Hi immanuel, Yes, I receive it and I was happy with the quality – just that I had to make the capsules myself and it takes time. Kind regards, Daniel 11月22日 下午9:23 嗨Immanuel， 是的，我收到了，我对质量很满意——只是我必须自己制作胶囊，这需要时间。 谢谢， 丹尼尔