Roger

Daniel,

Thank you for the great article and all the information. My mother has neuroendocrine tumour with large liver metastasis and I hope artemisia annua can help. I have a few questions:

1. How much iron is recommended / safe to take daily as part of the artemisinin treatment? E.g. is 50 mg safe? Does it work without iron supplements as well?

2. Do you think it’s safe to take 2 x 5g artemisia annua powder + 2 x super artemisinin (180 mg artemisinin + 20 mg artemisia annua leaf oil)? (Taking the powder at the same time with a capsule, twice a day.)
I know that the whole plant powder is supposed to be more effective, but a lot of articles reference artemisinin at quite high dosages (up to 1000 mg per day) and I’m not sure how much whole plant is needed to reach the same levels in blood as by taking 1000 mg pure artemisinin.

Thank you, Karolina

Karolinasays:
2017年7月27日下午2:33
丹尼尔，

感谢您提供的出色文章和所有信息。我母亲患有神经内分泌肿瘤，伴有大量肝转移，我希望青蒿素能够帮助她。我有几个问题：

1. 作为青蒿素治疗的一部分，每天建议摄入多少铁是安全的？例如，50毫克安全吗？不补充铁剂是否也有效？

2. 您认为每天服用2次5克青蒿素粉末+ 2次超级青蒿素（180毫克青蒿素+ 20毫克青蒿叶油）是否安全？（同时服用胶囊，每天两次。）
我知道整株植物粉末应该更有效，但很多文章都引用了相当高剂量的青蒿素（高达每天1000毫克），我不确定需要多少整株植物才能达到与每天摄入1000毫克纯青蒿素相同的血液水平。

谢谢，卡罗琳

Thanks a lot Ben for this great info! I totally agree, i.e. we need to have good sources of active supplements. In my view you touched an essential point, and i am considering now a way to verify that for other supplements as well. To my knowledge, here is one of the best sources on the whole plant Arte. Annua https://anamed.org/en/artemisia-annua-anamed.html However, I can not say if they validate all the points you mentioned. You can off course contact them and ask. Once, on of their members wrote a short note here but they never advertised which I also appreciated. In conclusion, you added very valuable points. Thank you.

Kind regards,
Daniel

Danielsays:
2017年6月20日上午12:16
非常感谢Ben提供的这些信息！我完全同意，即我们需要有好的活性补充剂来源。在我看来，你触及了一个重要的问题，我现在正在考虑一种验证其他补充剂的方法。据我所知，这是最好的整体青蒿草药来源之一  https://anamed.org/en/artemisia-annua-anamed.html  

然而，我无法确认他们是否验证了你提到的所有要点。你当然可以联系他们并询问。曾经，他们的一位成员在这里写过一张简短的纸条，但他们从未进行过广告，我也很感激。总之，你提出了非常有价值的观点。谢谢。

亲切的问候，
丹尼尔

from my reading around the chemistry and pharmacokinetics of Artemisia Annua it’s clear it is an unusual herb in several respects.
1, the active components are mainly found in tiny structures on the surface of the leaves and flowers/pre-flower buds in the top 1/3 of the plant – this is important when sourcing the herb as many sources out there are mainly stalks and stems ground up.
2, the active components in it ( notably artimisin – but also others) are heat, light and air sensitive – so drying and processing conditions are critical – to maintain the finished product potency
3, the herb is grown commercially in many countries for malaria medicine – and often high yield varieties are used that have 2-5x higher levels of active components – especially where it is grown for sudo-pharmacological drug production – but currently, herb suppliers do not typically have validated information about their sources – or the raw herb or finished herb product potency.
4, the chemicals in it have unusual absorption/excretion profile in humans/mammals – artemisinin blood concentrations in the blood are highest on the first day of dosing and fall rapidly to 25% of those by day 8. for this reason effective treatments are likely to be those that dose sufficiently from day 1 and continue for a relatively short course ( approx 30-40 days max ) – rather than slowly ramping up – or long-term use.

I highlight the above as I think it’s important for more of us to question our herb sources and ask for information on, growing processing and storage conditions, and concentration of active components in the herbs we buy. in the way, the industry will respond over time by providing more of this essential information to its customers. I also believe natural medicine should make the best use of the science we have available to us at this time, as well as the traditional and anecdotal resources.

I do not have references to hand but much of the above information is available online if you look for it – my knowledge of this herb stemmed from my initial reading of work by Stephen Buhner – a world renowned herbalist – and the references he cited in his books

if anyone locates a source of whole Artemesia Annua herb that can validate the above potency questions I would be very interested. As, other than growing your own, it seems very hard to find.

Bensays:
2017年6月15日下午1:10
从我对青蒿的化学和药代动力学的阅读中，可以清楚地看出，它在几个方面是一种不同寻常的草药。
1. 其活性成分主要存在于叶片和花朵/花蕾的表面微小结构中，在植物的顶部1/3中——这一点在采购该草药时很重要，因为许多来源主要是被研磨成茎和枝。
2. 其中的活性成分（尤其是青蒿素，但也包括其他成分）对热、光和空气敏感——因此干燥和加工条件至关重要——以保持成品的效力。
3. 该草药在许多国家被商业种植用于疟疾药物，并且通常使用高产量品种，其活性成分水平较高，尤其是在种植用于伪药学药物生产时——但目前，草药供应商通常没有关于其来源的验证信息，或者原始草药或成品草药的效力。
4. 其中的化学物质在人类/哺乳动物中有不同寻常的吸收/排泄特性——青蒿素在血液中的浓度在第一天剂量最高，然后迅速下降到第8天的25%。因此，有效的治疗很可能是从第一天开始足够剂量，并持续相对较短的疗程（最多约30-40天）——而不是缓慢递增或长期使用。

我强调以上内容，因为我认为更多的人应该质疑我们的草药来源，并要求有关种植、加工和储存条件以及我们购买的草药中活性成分的浓度的信息。随着时间的推移，该行业将通过向客户提供更多这些基本信息来作出回应。我还相信，自然疗法应该充分利用我们现有的科学知识，以及传统和个人经验。

我手头上没有参考资料，但上述信息大部分都可以在网上找到——我的对这种草药的了解源于我最初阅读了世界知名草药学家斯蒂芬·布纳（Stephen Buhner）的著作以及他引用的参考文献。

如果有人找到能验证上述效力问题的整体青蒿草药的来源，我会非常感兴趣。因为除了自己种植，似乎很难找到。

Thinus, would it be a normal / expectable reaction to Lucrin only?
cheers
W

Wonderingsays:
2017年6月9日下午1:20
Thinus，只接受Lucrin会是一种正常/可预期的反应吗？
祝好
W

Dear Thinus,
This is amazing.Could you please tell us more about your protocol.
Only coartem and Lucrin?Did you take chemo,surgery?
Kind Regards
Ergin

Erginsays:
2017年6月9日上午10:53
亲爱的Thinus，
这太神奇了。你能告诉我们更多关于你的治疗方案吗？
只有Coartem(复方蒿甲醚)和Lucrin(醋酸亮丙瑞林)吗？你接受过化疗、手术吗？
亲切的问候
Ergin

Hi Daniel
I am using the malaria tablet Coartem now since February 2016. I was diagnosed with tubular prostate cancer, Gleeson Score 8, PSA 901, black spot on the pelvis. Also received the terrible Lucrin injections until December 2016. My PSA is down to 0.23. A third bone scan last year August showed the black spot cleared up.
Kind Regards
Thinus Coetzee

Thinus Coetzeesays:
2017年6月1日晚上10:47
嗨，丹尼尔
自2016年2月以来，我一直在使用抗疟疾药物Coartem ( Coartem :复方蒿甲醚 )。我被诊断为管状前列腺癌，格里森评分为8，PSA为901，骨盆上有黑色斑点。还接受了可怕的Lucrin注射，直到2016年12月。我的PSA降至0.23。去年8月进行的第三次骨骼扫描显示黑色斑点已清除。
致以诚挚的问候
Thinus Coetzee

Hi,

it is also used against Lyme disease.

Wonderingsays:
2017年6月9日上午10:18
嗨，

青蒿素也被用来治疗莱姆病。

I have many clients whom are using artemisia for malaria,pile and skin diseases, I will also give it to cancer patients. Thanks for your transparent knowledge.

Shigella Philip Matejasays:
2017年1月5日上午11:36
我有很多客户正在使用青蒿素治疗疟疾、痔疮和皮肤病，我也会将其提供给癌症患者。感谢您的透明知识。

Daniel,
1. I know about Cooper, but it was necessary as I use high doses os Zinc in order to fix its deficiency caused fatal diet before diagnosis. I planned to suplement Zinc for 2-3 months which has just elapse.

2. Whole plant extract of Turmeric is simply Turmeric spice (I already use them), right?

3. What doses of ALA/B1/Omeoprazole/Metformin you suggest in combination withDCA?

5. Mebendazole and Cimetidine just purchased. Quercetin + Bromelain is already used. What about methyloglyohal? There is a lot of good info on your website (https://www.cancertreatmentsresearch.com/?p=1471) and it looks it should works also in CRC (https://www.ncbi.nlm.nih.gov/pubmed/27455418). Fast research shows Methyloglyoxal, 2-oxopropanal and Pyruvic Aldehyde are the same substances, right? I found it here: https://www.molport.com/shop/moleculelink/2-oxopropanal/1769006. Is that right choice?

6. Coriolus just purchsed.

4,7. Please let me know about good source of Artemisia annua row extract and retinoic acid. I found it here: https://www.molport.com/shop/search-results?searchkey=7FID7IHM2MR5G1B3PNL2SH, but there are a lot of versions: 9-cis-Retinoic Acid, Retinoic Acid, 11-cis Retinoic Acid, 13-cis-Retinoic acid, 13-cis Retinoic Acid Methyl Ester, 4-Oxo-9-cis-Retinoic Acid, 4-Keto 3-cis-Retinoic acid, 4-Keto all-trans-Retinoic Acid, 4-Keto all-trans-Retinoic Acid-d3, 9-cis Retinoic Acid Methyl Ester, 4-Keto all-trans-Retinoic Acid Methyl Ester. I don’t know the differences and don’t know the dosage in humans. To use it I need to be absolutely sure what I’m doing… Any advice?

Thank you very much again for your help!

Best regards,
Robert

Robsays:
2016年12月12日下午4:04
丹尼尔，

1. 我知道铜，但由于我在诊断前使用高剂量的锌以修复其缺陷造成的致命饮食，这是必要的。我计划补充锌2-3个月，刚刚过去。

2. 姜黄的全植物提取物就是姜黄香料（我已经在使用它们），对吗？

3. 与 DCA 结合使用时，您建议 ALA/B1/Omeoprazole/Metformin 的剂量是多少？

5. 刚刚购买了甲苯咪唑和西美替丁。槲皮素+菠萝蛋白酶已经在使用中。甲基乙醛怎么样？您的网站上有很多好信息（https://www.cancertreatmentsresearch.com/?p=1471），看起来它在 CRC 中也应该起作用（https://www.ncbi.nlm.nih.gov/pubmed/27455418）。快速研究显示甲基乙醛、2-氧丙酸醛和丙酮醛是相同的物质，对吗？我在这里找到了它：https://www.molport.com/shop/moleculelink/2-oxopropanal/1769006。这是正确的选择吗？

6. 刚刚购买了冬虫夏草。

4、7. 请告诉我哪里可以找到良好的青蒿素原提取物和维甲酸。我在这里找到了它：https://www.molport.com/shop/search-results?searchkey=7FID7IHM2MR5G1B3PNL2SH，但有很多版本：9-顺式维甲酸、维甲酸、11-顺式维甲酸、13-顺式维甲酸、13-顺式维甲酸甲酯、4-氧基-9-顺式维甲酸、4-酮-3-顺式维甲酸、4-酮全部反式维甲酸、4-酮全部反式维甲酸-d3、9-顺式维甲酸甲酯、4-酮全部反式维甲酸甲酯。我不知道它们的区别，也不知道人体内的剂量。要使用它，我需要绝对确定我在做什么... 有什么建议吗？

再次非常感谢您的帮助！

最诚挚的问候，
罗伯特

Dear Rob,

Thank you for the overview and for the nice words regarding the website.

Because your comment was so long it went directly to “Thresh” – I had to restore and approve that – that is why it took a bit more to see it published. If you will make a user account on this page I will not have to approve every of your future comment. It will be immediately visible, unless is detected as a spam due to e.g. too many links or too long, in which case it may go again to “Thresh”.

There are many questions I will try to shortly address all and if you have questions following the response just let me know.

1. I recognize most of those supplements but there is no major interaction that comes to my mind, based on my (limited) knowledge about most of them. I would however avoid the use of Zinc and Cooper since they are debatable and specifically Copper since it helps angio genesis.

2. There are many statements about various sources of Curcumin that are better than others. And there is marketing behind that. Curcumin is an extract from Turmeric. Curcumin is the most researched one but Turmeric has other powerful anti cancer components inside. For oral administration I would just pick a 1000mg capsule with piperine and use several of those each day. I would also administer a whole plant capsule with that (Turmeric) in order to get the benefits that may come from the other components. I would take this with some oil, e.g. Omega 3 capsules to help the absorption. With that, I would stop researching for the best source and move to a next treatment. Otherwise we may even write a PhD thesis on it and still not find the best version.

3. With DCA, I would start with 10mg/kg and if no issue increase to 20mg/kg. 5 days on and 2 days off to reduce chance for side effects. If there is serious benefit to the patient that should become visible at this dose. Omeprazole and even more Metformin will both help DCA but also themselves having anti cancer properties. ALA and caffeine indeed help against potential side effects as well as B1. I will once write a post on DCA.

4. I had a good source from Germany – I will search and if I find it I will let you know

5. For CRC Mebendazole is great indeed – up to 1000mg/day but always starting with lower dose with anything new. Quercetin is also very good. For some 3BP works great to debulk fast.

6. No specific opinion. Is a nice to have not necessarily a must have from my point of view. Coriolus can also help a lot the immune system and is cheaper.

7. Retinoic acid is easy available to my knowledge – I do not have the source at hand but if you remind me in the coming days I will give you a link to their website

I hope this answers your questions and helps.

Kind regards,
Daniel

Danielsays:
2016年12月8日上午11:06
亲爱的 Rob，

感谢您的概述和对网站的赞美之辞。

由于您的评论太长了，直接发送到了“阈值”-我不得不恢复并批准它-这就是为什么看起来需要更多时间才能发布它。如果您在此页面上创建用户帐户，我将无需批准您未来的每一条评论。它将立即可见，除非由于例如太多链接或太长的原因而被检测为垃圾邮件，否则可能会再次进入“阈值”。

问题很多：）我将尽量简要地回答所有问题，如果您对回答有任何疑问，请随时告诉我。

1. 我认识大多数这些补充剂，但根据我对大多数补充剂的（有限）了解，我没有想到重大的相互作用。但是，我会避免使用锌和铜，因为它们是有争议的，特别是铜，因为它有助于血管生成。

2. 关于姜黄素，有许多关于各种来源的声明，其中一些比其他的更好。而且背后有营销。姜黄素是从姜黄中提取出来的。姜黄素是研究最多的，但姜黄中还含有其他强大的抗癌成分。对于口服给药，我只会选择一颗含有胡椒碱的1000毫克胶囊，并每天服用几颗。我还会用整个植物胶囊（姜黄）一起服用，以获得可能来自其他成分的好处。我会用一些油，例如 Omega 3 胶囊来辅助吸收。除此之外，我会停止寻找最佳来源，并转向下一个治疗方法。否则，我们甚至可能会写一篇关于它的博士论文，但仍然找不到最佳版本。

3. 对于 DCA，我会从每公斤体重10毫克开始，如果没有问题，会增加到20毫克。5天用药，2天休息，以减少副作用的机会。如果对患者有严重的益处，这种剂量应该是可见的。奥美拉唑甚至是二甲双胍都会对 DCA 有帮助，但它们自己也具有抗癌特性。ALA 和咖啡因确实有助于减轻潜在的副作用，以及B1。我将在未来写一篇关于 DCA 的文章。

4. 我有一个德国的好来源-如果我找到了，我会告诉您

5. 对于 CRC，甲苯咪唑确实很棒-最多每天1000毫克，但始终从较低剂量开始尝试新的东西。槲皮素也非常好。对于一些人来说，3BP 可以迅速去除大量肿瘤。

6. 没有特定的意见。从我看来，这是一种好东西，而不是必备品。乌头菌也可以极大地帮助免疫系统，并且更便宜。

7. 根据我的了解，维甲酸很容易获取-我手头没有这个网站的链接，但如果您在未来几天提醒我，我会给您一个链接。

希望这些回答您的问题并有所帮助。

亲切的问候，
丹尼尔

Daniel,
Thank you for the answer and detailed explanation. I’m fighting with rectal cancer in a member of my family. It was diagnosed about 3 months ago and it is stage 3 (T3N1). The patient has also advanced cardiovascular disease CVD. Beacuse of coronary artery disease the chemotherapy was banned. Currently radiotherapy is in progress (5 x5Gy). After about 8 weeks the operation is planned. It is not simple case as we have two serious diseases, patient has 62 years and he its life style was fatal until now, so any changes are difficult to implement… Nevertheless

what I did until now in nutrition and suplementing area:

1. I completely changed the diet: it is now low fat, unprocessed plant only based diet based on rules described by Caldwell Esselstyn (http://www.dresselstyn.com/site/), Colin Campbell (http://nutritionstudies.org/), Dean Ornish (http://deanornish.com/) and finally David Servan-Schreiber (http://www.anticancerbook.com/) to use most anticancer nutrition products.

2. I applied a lot of suplements, extracts and cancer treatmens. I had a few goals:
– elimination of nutritional deficiencies,
– stimulation of the immune system,
– direct fighting with cancer (increasing apoptosis, inhibition of proliferation and angiogenesis),
– stopping CVD and reversal of atherosclerosis,
– necessary supplementation in the vegan diet.

I’ve used until now:
– vitamins: D3, K2-MK4, K2-MK7, C (as acerola extract), B12,
– minerals: zinc and copper (for a change), selenium, iodine, magnesium malate,
– short and long chain Omega3 (ALA from flax/chia/hemp protein and EPA/DHA from microalgal oils),
– others: Q10, CLA (Conjugated Linoleic Acid), ALA (Alpha Lipoic Acid), beta-alanine + histidine (for increasing carnosine synthesis), NAC+glycine+glutamine (for increasing glutathion synthesis; I stopped glutamine as I found CRC likes it), astaxanthin,
– lot of plant extracts: piperinum, garlic extract, tumeric (row and as a Theracurmin), black and cayenne pepper (for increasing curcumin bioavailability), milk thistle (row and as a strong silymarin extract – synergistic with curcumin), grape seed (a lot of OPC), cat’s claw, resveratrol, ginkgo biloba, graviola leaves, gotu kola, hylandia dockrillii, ashwagandha, houttuynia, boswellia, olive leafs, green tea, fisetin, broccoli (as row seeds and as BroccoMax), shatavari, echinacea, noni, black cumin, moringa oleifera leaves, quercetin+bromelain, acai, cranberries,
– mushrooms: oyster, cordyceps, chaga, reishi, shitake,
– BioBran (Bibran): http://www.daiwa-pharm.com/english/product/biobran.html, http://www.biobran.org/.

All used extracts has scientifically proven anticancer properties, sometimes in vitro or in mouse/rats, but it
has. Daniel a few more questions to you:

1. As it is not possible to use all of the above extracts and we have 4 weeks to reduce main tumor size, then please let me know what to use and what not. Maybe you also know some bad interactions between the above extracts, then let me know (in example I found that chaga can may magnify the effects of anticoagulant medications such as aspirin which we use; patient also uses beta blockers for hypertension).

2. Regarding curcumin – I found that the best bioavailability has Theracurmin, so I choosed it. Theracurmin is better than BCM-95, BCM-95 is better than row curcumin and row curcumin is better than turmeric. Example research: https://www.ncbi.nlm.nih.gov/pubmed/25994138. Let me know what do you think.

3. I plan to start NaDCA. What doses you suggest and what additions should be used. I found information about thiamine, ALA (alpha lipoic acid) and caffeine (preventing NaDCA-induced neuropathy) and omeoprasole (synergistic effect: https://www.ncbi.nlm.nih.gov/pubmed/22580646, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362455/).
Please advice.

4. Currently we use Artemisinin 2 x 200g orally administrated. According to your and Meech information it should be safe with NaDCA. Also, do you know good sources of row Artemisia annua extract?

5. What other treatments you suggest? According to your website (in my opinion the best – congratulations!) I thought about mebendazole, methylglyoxal. Any suggestions will be appreciated.

6. What do you think about BioBran? Treatment is in progress (3 x 1g MGN-3) and is not cheap, so if there is something definitely better then let me know.

7. I found the information about retinoic acid in CRC (https://www.cancertreatmentsresearch.com/?p=137, https://www.sciencedaily.com/releases/2016/08/160830130817.htm). Retinoic acid it is not easy available and I don’t know what doses should be used in human, but maybe a lot of carrot juice and retinol suplementation would make the same effect?

Thank you very much for your help!

Best regards,
Rob

Robsays:
2016年12月8日凌晨12:38
丹尼尔，

非常感谢你的回答和详细的解释。我的家人患有直肠癌，我正在与之作斗争。大约3个月前被诊断为3期（T3N1）的癌症。患者还患有晚期心血管疾病。由于冠状动脉疾病，化疗被禁止。目前正在进行放疗（5 x 5Gy）。大约8周后计划手术。这不是一个简单的情况，因为我们有两种严重的疾病，患者已经62岁了，他的生活方式直到现在都是致命的，所以任何变化都很难实施……尽管如此，到目前为止我在营养和补充领域所做的事情有：

1. 我完全改变了饮食：现在是低脂、未加工的植物为主的饮食，基于 Caldwell Esselstyn、Colin Campbell、Dean Ornish 和最后 David Servan-Schreiber 的规则，以使用最抗癌的营养产品。

2. 我应用了大量的补充剂、提取物和癌症治疗方法。我的几个目标是：
   - 消除营养缺乏，
   - 刺激免疫系统，
   - 直接与癌症作斗争（增加细胞凋亡、抑制增殖和血管生成），
   - 阻止心血管疾病并逆转动脉粥样硬化，
   - 在纯素饮食中必要的补充。

我目前使用了：
   - 维生素：D3、K2-MK4、K2-MK7、C（作为樱桃西红柿提取物）、B12，
   - 矿物质：锌和铜（轮流使用）、硒、碘、苹果酸镁，
   - 短链和长链 Omega3（亚麻籽/奇亚籽/大麻蛋白的ALA和海藻油的EPA/DHA），
   - 其他：Q10、共轭亚油酸（CLA）、α-硫辛酸（Alpha Lipoic Acid）、β-丙氨酸+组氨酸（用于增加肌肉肌酸的合成）、NAC+甘氨酸+谷氨酸（用于增加谷胱甘肽的合成；我停止了谷氨酸，因为我发现 CRC 喜欢它）、虾青素、植物提取物：胡椒碱、大蒜提取物、姜黄素（生和作为 Theracurmin）、黑胡椒和辣椒粉（增加姜黄素的生物利用度）、水飞蓟（生和作为强力水飞蓟提取物 - 与姜黄素协同作用）、葡萄籽（大量的OPC）、猫爪、白藜芦醇、银杏叶、佛手柑叶、阿胶、牛至、乌林麦、乳叶植物、绿茶、花青素、西兰花（作为生籽和 BroccoMax）、天那磨、紫锥菊、诺丽、黑种子、辣木叶、槲皮素+溴酸（Quercetin+bromelain）、巴西莓、蔓越莓、
   - 蘑菇：牡蛎、虫草、灵芝、香菇，
   - BioBran（Bibran）：http://www.daiwa-pharm.com/english/product/biobran.html, http://www.biobran.org/

所有使用的提取物都有科学证明的抗癌作用，有时是在体外或小鼠/大鼠中，但它们都有。丹尼尔，我还有几个问题要问你：

1. 由于不可能使用所有上述提取物，我们有4周的时间来减少主要肿瘤的大小，请告诉我该使用什么，不该使用什么。也许你还知道上述提取物之间的一些不良互动，那么请告诉我（例如，我发现虫草可能会增加抗凝药物（如阿司匹林）的效果，我们使用它；患者还使用β受体阻滞剂治疗高血压）。

2. 关于姜黄素 - 我发现 Theracurmin 的生物利用度最高，所以我选择了它。 Theracurmin 比 BCM-95 好，BCM-95 比生姜黄素好，生姜黄素比姜黄素好。例如研究：https://www.ncbi.nlm.nih.gov/pubmed/25994138 请告诉我你的看法。

3. 我计划开始使用 NaDCA。你建议使用什么剂量以及应该使用什么添加剂。我找到关于硫胺素、α-硫辛酸和咖啡因（预防 NaDCA 引起的神经病理学）以

及奥美拉唑（协同作用：https://www.ncbi.nlm.nih.gov/pubmed/22580646、https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362455/ ）的信息。请给予建议。

4. 目前我们口服使用青蒿素 2 x 200g。根据你和 Meech 的信息，与 NaDCA 一起使用应该是安全的。此外，你知道优质的生 Artemisia annua 提取物的来源吗？

5. 你推荐什么其他治疗？根据你的网站（在我看来是最好的 - 祝贺！），我考虑了甲苯咪唑和甲基乙醛。任何建议都将不胜感激。

6. 你对 BioBran 有什么看法？治疗正在进行中（3 x 1g MGN-3），并且不便宜，所以如果有更好的选择，请告诉我。

7. 我发现了关于 CRC 中维甲酸的信息（https://www.cancertreatmentsresearch.com/?p=137、https://www.sciencedaily.com/releases/2016/08/160830130817.htm）。维甲酸不容易获取，我不知道在人体中应该使用多少剂量，但也许大量的胡萝卜汁和维生素 A 补充剂会产生相同的效果？

非常感谢您的帮助！

最诚挚的问候，
Rob

Hi Rob,

Thank you Meech for helping out with teh response.

1. I would not worry about combining the two as long as they are used in the oral version both. But if that is given IV, I would indeed follow the treatments with blood tests every week or so.

2. In general, I would not worry about combination with anti oxidants unless you use very strong anti oxidants such as NAC. If that is the case, I would indeed give them some hours latter or even better stop them while using pro oxidant treatments. When the treatments are performed IV, I would clearly not combine anti oxidants with pro oxidants, not even days latter, as the antioxidants will cancel out the effects of the pro oxidant treatments. That is based on facts. To be clear, I am speaking about the use of strong antioxidants such as NAC and ALA.

3. It doesn’t really matter because of the following: if given orally I prefer the whole plant from an effectiveness point of view; if given IV only Artesunate is available (so far and to my knowledge).

Note: Based on personal experience Artesunate combined with Vitamin C, both given IV, may lead to decline of hemoglobin so I would avoid this combination – however, this change is reversible and hemoglobin will come back once the treatment is ended.

I hope this helps.

Kind regards,
Daniel

Danielsays:
2016年12月7日下午3:36
嗨 Rob，

谢谢 Meech 的帮助。

1. 只要两者都是口服版本，我不会担心它们的结合。但如果是静脉注射，我确实会在治疗后每周进行一次血液检查或者更频繁一些。

2. 一般来说，我不会担心与抗氧化剂的结合，除非你使用非常强的抗氧化剂，比如 NAC。如果是这种情况，我会在之后几个小时内甚至更好地停止它们，或者在使用氧化剂治疗时停止它们。当治疗是静脉注射时，我绝对不会在氧化剂治疗中结合抗氧化剂，甚至是几天后，因为抗氧化剂会取消氧化剂治疗的效果。这是基于事实的。要明确，我说的是对于如 NAC 和 ALA 这样的强抗氧化剂的使用。

3. 这并不重要，因为以下原因：如果是口服给药，从有效性的角度来看，我更喜欢整株植物；如果是静脉注射，目前我只知道有 Artesunate 可用。

注：根据个人经验，静脉注射的 Artesunate 与维生素 C 结合使用可能导致血红蛋白下降，所以我会避免这种组合——然而，这种变化是可逆的，一旦治疗结束，血红蛋白就会恢复。

希望这有所帮助。

亲切的问候，
丹尼尔

Hi Rob, I’ve been using NaDCA and artemisinin tea for a while now and have not experienced any worsening in liver enzymes, etc. I haven’t been taking a large dose of artemisinin though, just one cup daily generally.

Meechsays:
2016年12月5日凌晨12:41
嗨，Rob，我一直在使用NaDCA和青蒿素茶，但是到目前为止，我没有经历肝酶等方面的恶化。不过，我没有服用大剂量的青蒿素，通常只是每天一杯。

Daniel,
I found the case report about fatal connection Artesuante + NaDCA:

https://www.ncbi.nlm.nih.gov/pubmed/27774434
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053977/
http://journal.frontiersin.org/article/10.3389/fonc.2016.00204/full

1. What do you think? Is it safe to use both medicaments together? How about connection of Artemisinin and NaDCA, both orally administrated?

2. And how about using anti oxidants? I know it is not recommended, but shoud it be stopped at all or it is enough to take Artemisinin a few hours after anti oxidants?

3. Is Artesuante better than Artemisinin in cancer treatment?

Thank you for your help

Best regards,
Rob

Robsays:
2016年12月3日晚上9:44
丹尼尔，
我找到了关于致命联系 Artesuante + NaDCA 的案例报告：

https://www.ncbi.nlm.nih.gov/pubmed/27774434
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053977/
http://journal.frontiersin.org/article/10.3389/fonc.2016.00204/full

1. 你认为怎么样？同时使用这两种药物安全吗？口服青蒿素和NaDCA的连接如何？

2. 使用抗氧化剂怎么样？我知道不建议使用，但是是完全停止还是只需要在抗氧化剂几小时后服用青蒿素就足够了？

3. 在癌症治疗中，Artesuante 是否比 Artemisinin 更好？

谢谢你的帮助：）

最好的问候，
Rob

Hi, thanks for your questions:
1. the answer is in the post
2. i would probably check after one month if there is still progression or not and continue or stop accordingly
3. I am not aware of any interaction between the two so I would use them at the same time

Danielsays:
2016年10月16日晚上9:21
嗨，谢谢你的问题：
1. 答案在帖子中。
2. 我可能会在一个月后检查是否仍然存在进展，并相应地继续或停止。
3. 我不知道两者之间是否有任何相互作用，所以我会同时使用它们。

Hi Daniel,
You have given a very brief literature on Artimesia Annua on MALARIA & CANCER .
1.Leaf powder of art.annua what is the dosage for cancer treatment ?
2. What is the period of dosage ?
3. Along with cannibis oil Artmisia annua can be taken ?
Kindly clarify.

jarisenthilsays:
2016年10月13日下午3:08
嗨，丹尼尔，
你对青蒿素在疟疾和癌症方面的文献进行了非常简要的介绍。
1. 对于癌症治疗，青蒿素的叶粉剂剂量是多少？
2. 剂量周期是多长？
3. 青蒿素和大麻油可以一起服用吗？
请澄清。

Thanks for replying.

Also, would like to know if there may be interference of antioxidants with Arte. Should one continue curcumin, carrot juice (oxylates), vitamin C, asparagus, baking soda, wheatgrass, other vitamin and mineral supplements with Arte. If so, what time gap in your opinion will be reasonable to avoid any interference.

PSsays:
2016年6月20日上午9:30
感谢回复。

此外，我想知道抗氧化剂是否会与青蒿素产生干扰。在服用青蒿素的同时，是否应该继续服用姜黄素、胡萝卜汁（草酸盐）、维生素C、芦笋、小苏打、小麦草、其他维生素和矿物质补充剂。如果是这样，您认为应该保持多长时间间隔才合理，以避免任何干扰。

Hi PS, Thanks for the feedback. Regarding your question, I think Arte is similar to Vitamin C, i,e, one of the main anticancer mechanism is based on its interaction with Fe. So you want to have Arte reaching the cancer cell in order to interact with intracellular Fe and kill cancer cells. Due to this, I would avoid taking Arte with or after high Fe containing foods as it may end up reacting with Fe before reaching its target. Taking Fe chelators prior to Arte may help too. Kind regards.

Danielsays:
2016年6月18日晚上8:41
嗨 PS，感谢反馈。关于你的问题，我认为青蒿素类似于维生素C，即，其主要的抗癌机制之一是基于它与铁的相互作用。因此，你希望青蒿素达到癌细胞，以便与细胞内铁发生作用并杀死癌细胞。由于这个原因，我会避免在高铁含量的食物中服用青蒿素，因为它可能在到达目标之前与铁发生反应。在服用青蒿素之前服用铁螯合剂也可能有所帮助。亲切的问候。

Hi Daniel,

U have been doing a very good job and it gives hope to everyone who’s fighting this kind of disease.
Can you also pls explain which supplements/ food should not be taken or what time gap should be maintained along with artemisinin.

Regards

PSsays:
2016年6月18日上午11:44
嗨，丹尼尔，

你一直做得很好，给所有正在与这种疾病作斗争的人带来了希望。
您是否也可以解释一下，服用青蒿素时不应该服用哪些补充剂/食物，或者应该保持多长时间间隔？

问候

Hi Nicole,

It is well known in the scientific literature that cancer cells usually increase the input of iron and inhibit its output, leading to intracellular iron accumulation. Given this fact, it is natural to expect that cancer cells have accumulated enough Iron.

If cancer cells don’t have enough Iron, it means they can not develop, and I woudl be happy to keep that status, while I would find it risky to give them fuel for division when they don’t have enough iron. If on the other hand, cancer cells have enough Iron (as we woudl expect based on science), there is no point to further supplement.

Furthermore, it has been shown that the availability of extracellular Iron reduces the effectiveness of Vitamin C https://www.nature.com/articles/srep05955 and I woudl expect the same applies to Artemisinin.
(I discussed this paper some years back here https://www.cancertreatmentsresearch.com/high-dose-vitamin-c-cancer/ )

In this context, the authors in the paper above even suggested it may be best to use Iron chelators prior to the use of Vitamin C in cancer therapy in order to remove some of the extracellular iron, and as a result enhance the effect of Vitamin C. This concept woudl apply to Artemisinin treatment strategy as well, and we therefore could argue it is even the opposite to the concept of using Iron prior to Artemisinin that is often promoted online (which is logical at first, without going into the details mentioned above).

Iron chelator typically used at integrative clinics is EDTA.

Kind regards,
Daniel

Danielsays:
2022年6月3日凌晨3:46
嗨，妮可，

科学文献中广为人知的是，癌细胞通常增加铁的摄入并抑制其输出，导致细胞内铁积累。基于这个事实，自然而然地可以预期，癌细胞已经积累了足够的铁。

如果癌细胞缺乏足够的铁，这意味着它们无法发展，我会很高兴保持这种状态，而在它们缺乏足够的铁时给它们提供分裂的燃料会被认为是有风险的。另一方面，如果癌细胞有足够的铁（根据科学预期），那么进一步补充就没有意义了。

此外，已经有研究表明，细胞外铁的可用性会降低维生素C的有效性 https://www.nature.com/articles/srep05955 ，我认为同样的情况也适用于青蒿素。
（我在几年前在这里讨论过这篇论文 https://www.cancertreatmentsresearch.com/high-dose-vitamin-c-cancer/ ） 

在这种情况下，上述论文的作者甚至建议在癌症治疗中使用维生素C之前先使用铁螯合剂，以去除部分细胞外铁，从而增强维生素C的作用。这个概念也适用于青蒿素治疗策略，因此我们可以争论说，甚至反对常常在网上宣传的先使用铁然后再使用青蒿素的概念（起初这是合乎逻辑的，没有涉及上述细节）。

集成诊所通常使用的铁螯合剂是EDTA。

亲切的问候，
丹尼尔

@daniel. why did you say your personally wouldn’t do the Iron if getting IV Art??

nnj925说：
2022年6月2日晚上11:38
@daniel。你为什么说你个人不会做铁静脉输液？